ANDOVIMPAMIDE 200 MG I.V. INF. VIAL

PHARMACOLOGY PRECISE MECHANISM OF ACTION IS UNKNOWN; HOWEVER LACOSAMIDE SELECTIVELY ENHANCES SLOW INACTIVATION OF VOLTAGE-GATED SODIUM CHANNELS RESULTING IN STABILIZATION OF HYPEREXCITABLE NEURONAL MEMBRANES AND INHIBITION OF REPETITIVE NEURONAL FIRING. INDICATIONS AND USAGE ORAL ADJUNCTIVE TREATMENT OF PARTIAL-ONSET SEIZURES. PARENTERAL ADJUNCTIVE TREATMENT OF PARTIAL-ONSET SEIZURES WHEN ORAL ROUTE IS NOT FEASIBLE. DOSAGE AND ADMINISTRATION PARTIAL-ONSET SEIZURES ADULTS AND CHILDREN 17 Y OF AGE AND OLDER PO/IV START WITH 50 MG TWICE DAILY. THE DOSAGE MAY BE INCREASED BY 50 MG TWICE DAILY AT WEEKLY INTERVALS UP TO THE RECOMMENDED MAINTENANCE DOSAGE OF 200 TO 400 MG/DAY BASED ON RESPONSE AND TOLERABILITY. HEPATIC FUNCTION IMPAIRMENT ADULTS AND CHILDREN 17 Y OF AGE AND OLDER PO/IV TITRATE THE DOSE WITH CAUTION. MAX DOSAGE OF 300 MG/DAY IS RECOMMENDED IN PATIENTS WITH MILD OR MODERATE HEPATIC IMPAIRMENT. NOT RECOMMENDED IN PATIENTS WITH SEVERE HEPATIC IMPAIRM