LORANOVIL 8MG 20 F.C. TABS

ABOUT LORNOXICAM NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) OF THE OXICAM CLASS WITH ANALGESIC (PAIN RELIEVING) ANTI-INFLAMMATORY AND ANTIPYRETIC (FEVER REDUCING) PROPERTIES. IT IS AVAILABLE IN ORAL AND PARENTERAL FORMULATIONS. MECHANISM OF ACTION OF LORNOXICAM LIKE OTHER NSAIDS LORNOXICAM INHIBITS PROSTAGLANDIN BIOSYNTHESIS BY BLOCKING THE ENZYME CYCLOOXYGENASE. LORNOXICAM INHIBITS BOTH ISOFORMS IN THE SAME CONCENTRATION RANGE THAT IS THE RATIO OF COX-1 INHIBITION TO COX-2 INHIBITION IS 1:1. IT READILY PENETRATES INTO THE SYNOVIAL FLUID. INTERACTIONS FOR LORNOXICAM 1.VITAMIN K ANTAGONISTS LIKE WARFARIN INCREASES THE RISK OF BLEEDING. 2.CICLOSPORIN CAN LEAD TO REDUCED KIDNEY FUNCTION AND TO ACUTE RENAL FAILURE IN RARE CASES. 3.LORNOXICAM CAN ALSO INCREASE THE ADVERSE EFFECTS OF LITHIUM METHOTREXATE AND DIGOXIN AND ITS DERIVATIVES. 4.THE EFFECT OF DIURETICS ACE INHIBITORS AND ANGIOTENSIN II RECEPTOR ANTAGONISTS CAN BE REDUCED BUT THIS IS ONLY RELEVANT IN PATIENT