LOWTIMIB COMP 10/20MG 10 F.C. TAB

About EzetimibeSCholesterol Absorption Inhibitor 2-Azetidinone derivative Hypolipidemic agent.SMechanism of Action of EzetimibeSIt reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine where it inhibits the absorption of cholesterol from the diet. Specifically it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium a critical mediator of cholesterol absorption. This decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells thus decreasing levels in the blood plasma.SIndications for EzetimibeS1. Adjunct to dietary measures and statin in primary and homozygous familial hypercholesterolaemia S2. Adjunct to dietary measures in homozygous familial sitosterolaemia SInteractions for EzetimibeSCyclosporin: Plasma concentraction of ezetimibe increased. Lipid-regulating drugs: Avoid concomitant use with fibrates.