LUNGITINIB 150 MG 30 F.C. TABS
سعر LUNGITINIB 150 MG 30 F.C. TABS
7678.00 جنية
الشركة المنتجة لـ LUNGITINIB 150 MG 30 F.C. TABS
HIKMA SPECIALIZED PHARMACEUTICALS
المادة الفعالة LUNGITINIB 150 MG 30 F.C. TABS
ERLOTINIB
معلومات عن LUNGITINIB 150 MG 30 F.C. TABS
Pharmacology
Reversibly inhibits overall epidermal growth factor receptor (HER1/EGFR) - tyrosine kinase activity. Intracellular phosphorylation is inhibited which prevents further downstream signaling resulting in cell death. Erlotinib has higher binding affinity for EGFR exon 19 deletion or exon 21 L858R mutations than for the wild type receptor.
Indications
Non-small cell lung cancer metastatic: Treatment of metastatic non-small cell lung cancer (NSCLC) in tumors with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an approved test either as first-line maintenance or as second or greater line treatment after progression following at least 1 prior chemotherapy regimen.
Limitations of use: Use in combination with platinum-based chemotherapy is not recommended. Safety and efficacy of treatment for metastatic NSCLC with EGFR mutations other than exon 19 deletion or exon 21 (L858R) substitution have not been est