MESALAJED 400MG 10 DELAYED REL. TAB

ABOUT MESALAZINE 5-AMINOSALICYLIC ACID DERIVATIVE ANTI-INFLAMMATORY BOWEL AGENT. MECHANISM OF ACTION OF MESALAZINE MESALAZINE EXERTS ITS ANTI-INFLAMMATORY ACTION BY INHIBITING LIPOXYGENASE ENZYME. THIS WILL LEADS TO DECREASED PRODUCTION OF PRO-INFLAMMATORY LEUKOTRIENES (LTB4) AND 5-HYDROXY EICOSA TETRA ENOIC ACIDS (HETE) IN THE INTESTINAL WALL. IT INHIBITS THE PRODUCTION OF INFLAMMATORY MEDIATORS LIKE INTERLEUKIN-1 TUMOR NECROSIS FACTOR-ALPHA ETC. INDICATIONS FOR MESALAZINE 1.ULCERATIVE COLITIS 2.CROHN`S DISEASE 3.PROCTITIS AND PROCTOSIGMOIDITIS (USE ONLY SUPPOSITORIES)