METCLAMIDE 2.5/500MG 30 TAB

ABOUT METFORMIN BIGUANIDE DERIVATIVE ORAL ANTI-DIABETIC. MECHANISM OF ACTION OF METFORMIN IT IS A BIGUANIDE WHICH EXERTS ANTIDIABETIC ACTION. THE DRUG SUPPRESSES GLUCONEOGENESIS IN LIVER AND THUS SUPPRESSES HEPATIC GLUCOSE OUTPUT. IT ENHANCE INSULIN MEDIATED GLUCOSE DISPOSAL IN MUSCLE AND ADIPOSE TISSUE. IT ENHANCE GLUT1 (GLUCOSE TRANSPORTER-1) TRANSPORT FROM INTRACELLULAR SITE TO PLASMA MEMBRANE. IT ALSO INTERFERES WITH RESPIRATORY CHAIN IN MITOCHONDRIA AND PROMOTES PERIPHERAL GLUCOSE UTILIZATION BY INCREASING ANAEROBIC GLYCOLYSIS. IT INHIBITS INTESTINAL ABSORPTION OF GLUCOSE OTHER HEXOSE SUGARS AMINO ACIDS AND VITAMIN B12. IT ALSO IMPROVES LIPID PROFILE IN TYPE-2 DIABETICS. INDICATIONS FOR GLIBENCLAMIDE 1. NON INSULIN DEPENDENT DIABETES MELLITUS. INTERACTIONS FOR GLIBENCLAMIDE HYPOGLYCAEMIC EFFECT OF GLIBENCLAMIDE IS ENHANCED BY: ANTICOAGULANTS ANDROGENS CHLORAMPHENICOL CLOFIBRATE FENFLURAMINE FLUCONAZOLE GEMFIBROZIL HISTAMINE H2 ANTAGONISTS MAGNESIUM SALTS METHYL