METOJECT 20 MG/0.4 ML I.M./I.V./S.C. PREFILLED SYRINGE
سعر METOJECT 20 MG/0.4 ML I.M./I.V./S.C. PREFILLED SYRINGE
295.00 جنية
الشركة المنتجة لـ METOJECT 20 MG/0.4 ML I.M./I.V./S.C. PREFILLED SYRINGE
MEDAC > SUNNY MEDICAL
المادة الفعالة METOJECT 20 MG/0.4 ML I.M./I.V./S.C. PREFILLED SYRINGE
METHOTREXATE
معلومات عن METOJECT 20 MG/0.4 ML I.M./I.V./S.C. PREFILLED SYRINGE
About Methotrexate
Antimetabolite antifolate Immunosuppressant Antineoplastic Antirheumatic.
Mechanism of Action of Methotrexate
Drug inhibits the enzyme dihydrofolate reductase (DHFR) which catalyses the conversion of dihydrofolate to active tetrahydrofolate.It is an important step in the folic acid synthesis. Folic acid is needed for the de novo nucleoside thymidine required for DNA synthesis. Drug therefore inhibit the synthesis of DNA RNA and protein. In lower doses it inhibit the enzyme involved in purine metabolism leading to accumulation of adenosine or the inhibition of T-cell activation and suppression of intercellular adhesion molecule expression by T-cells.
Indications for Methotrexate
1. Acute lymphoblastic leukemia
2. Choriocarcinoma
3. Burkitt`s lymphoma
4. Meningeal leukemia
5. Lymphosarcoma
6. Hydatidiform mole
7. Psoriasis
8. Rheumatoid arthritis
9. Corticosteroid dependant asthma
10. Non metastatic osteosarcoma
11. Mycosis fungoides
