MOMSONE 0.1% CREAM 20 GM

About Mometasone A glucocorticoid steroid Anti psoriatic anti asthma anti inflammatory. Mechanism of Action of Mometasone Mometasone is a topical medium potency glucocorticoid. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response. The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages endothelium and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins leukotrienes (LT) and platelet activating factor