MOTIPRID 10MG 10 TAB. (N/A)

About Cisapride A serotonin 5-HT4 receptor agonist parasympathomimetic Gastrointestinal prokinetic agent. Mechanism of Action of Cisapride Cisapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Cisapride produces 5HT3 antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity lower oesophageal sphincter tone and enhances intestinal propulsive activity.