APHTHTAB 2MG 20 BUCCAL BIOADHESIVE TAB

DESCRIPTION : AMLEXANOX IS AN ANTIALLERGIC DRUG CLINICALLY EFFECTIVE FOR ATOPIC DISEASES ESPECIALLY ALLERGIC ASTHMA AND RHINITIS. AMLEXANOX AS A TOPICAL PASTE IS A WELL TOLERATED TREATMENT OF RECURRENT APHTHOUS ULCERS. RECURRENT APHTHOUS ULCER (RAU) IS THE MOST PREVALENT ORAL MUCOSAL DISEASE IN HUMANS ESTIMATED TO AFFECT BETWEEN 5% AND 50% OF THE GENERAL POPULATION. INDICATION : USED AS A PASTE IN THE MOUTH TO TREAT APHTHOUS ULCERS MECHANISM OF ACTION : AMLEXANOX HAS ANTI-INFLAMMATORY AND ANTIALLERGIC PROPERTIES. IT INHIBITS CHEMICAL MEDIATORY RELEASE OF THE SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A) AND MAY HAVE ANTAGONISTIC EFFECTS ON INTERLEUKIN-3. WHEN CELLS ARE UNDER STRESS THEY RELEASE AN INACTIVE FORM OF HUMAN FIBROBLAST GROWTH FACTOR 1 (FGF-1) A POTENT MITOGEN (ENTITY THAT CAUSES MITOSIS). AMLEXANOX BINDS TO FGF1 INCREASING ITS CONFORMATIONAL STABILITY STERICALLY BLOCKING CU(2+) INDUCED OXIDATION WHICH NORMALLY LEADS TO ACTIVATION OF FGF-1.