ONKOTRONE 20 MG VIAL (N/A)

About Mitoxantrone An Anthracenedione derivative a type II topoisomerase inhibitor Anti-neoplastic. Mechanism of Action of Mitoxantrone This drug shows its anticancer activity by different mechanisms. Drug intercalates the DNA cause inter/intra strand cross linking. The drug can also bind to the topoisomerase enzyme2 which is necessary for the cell to divide and so grow into 2 new cells. If the drug binds with DNA it gets tangled up and the cell cannot divide. This is cell cycle phase-nonspecific Indications for Mitoxantrone 1. Chronic myelogenous leukemia 2. Non Hodgkins disease 3. Breast cancer 4. Acute non lymphocytic leukemia 5. Hormone-refractory prostate cancer 6. Multiple sclerosis 7. Lymphomas 8. Gastric cancer 9. Liver cancer 10. Ovarian cancer 11. Prostate cancer