OXIS 4.5MCG/DOSE TURBUHALER (CANCELLED)

Mechanism of action The pharmacologic effects of beta2-adrenoceptor agonist drugs including formoterol are at least in part attributable to stimulation of intracellular adenyl cyclase the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3 5 -adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibits the release of pro-inflammatory mast-cell mediators such as histamine and leukotrienes. Formoterol also inhibits histamine-induced plasma albumin extravasation in anesthetized guinea pigs and inhibits allergen-induced eosinophil influx in dogs with airway hyper-responsiveness. The relevance of these in vitro and animal findings to humans is unknown.