ARPIMUNE ME 25MG 50 S.G. CAPS

ABOUT CYCLOSPORIN A A CYCLIC NONRIBOSOMAL PEPTIDE(11 AMINO ACIDS) IMMUNOSUPPRESSANT DRUG ORGAN TRANSPLANT REJECTION PREVENTION. MECHANISM OF ACTION OF CYCLOSPORIN A CYCLOSPORINE BINDS TO THE CYTOSOLIC PROTEIN CYCLOPHILIN (IMMUNOPHILIN) OF IMMUNOCOMPETENT LYMPHOCYTES ESPECIALLY T-LYMPHOCYTES. THIS COMPLEX INHIBITS CALCINEURIN WHICH IS RESPONSIBLE FOR ACTIVATING THE TRANSCRIPTION OF INTERLEUKIN 2. IT ALSO INHIBITS LYMPHOKINE PRODUCTION AND INTERLEUKIN RELEASE AND THEREFORE LEADS TO REDUCED FUNCTION OF EFFECTER T-CELLS. DRUG PREVENTS MITOCHONDRIAL PT PORE FROM OPENING AND INHIBITS CYTOCHROME C RELEASE AND ALSO APOPTOSIS INDUCED BY IT. INDICATIONS FOR CYCLOSPORIN A 1. ORGAN TRANSPLANT REJECTION 2. RHEUMATOID ARTHRITIS 3. CROHN`S SYNDROME 4. NEPHROTIC SYNDROME 5. PSORIASIS 6. ULCERATIVE COLITIS 7. UVEITIS 8. NEUROPROTECTION IN TRAUMATIC BRAIN INJURY 9. APLASTIC ANEMIA 10. MYASTHENIA GRAVIS 11. DERMATOMYOSITIS