PERDERM 0.05% OINT. 10 GM

DESCRIPTION ALCLOMETASONE IS SYNTHETIC GLUCOCORTICOID STEROID FOR TOPICAL USE IN DERMATOLOGY AS ANTI-INFLAMMATORY ANTIPRURITIC ANTIALLERGIC ANTIPROLIFERATIVE AND VASOCONSTRICTIVE AGENT. INDICATION: FOR THE RELIEF OF THE INFLAMMATORY AND PRURITIC MANIFESTATIONS OF CORTICOSTEROID-RESPONSIVE DERMATOSES. MECHANISM OF ACTION THE MECHANISM OF THE ANTI-INFLAMMATORY ACTIVITY OF THE TOPICAL STEROIDS IN GENERAL IS UNCLEAR. HOWEVER CORTICOSTEROIDS ARE THOUGHT TO ACT BY THE INDUCTION OF PHOSPHOLIPASE A2 INHIBITORY PROTEINS COLLECTIVELY CALLED LIPOCORTINS. IT IS POSTULATED THAT THESE PROTEINS CONTROL THE BIOSYNTHESIS OF POTENT MEDIATORS OF INFLAMMATION SUCH AS PROSTAGLANDINS AND LEUKOTRIENES BY INHIBITING THE RELEASE OF THEIR COMMON PRECURSOR ARACHIDONIC ACID. ARACHIDONIC ACID IS RELEASED FROM MEMBRANE PHOSPHOLIPIDS BY PHOSPHOLIPASE A2. ALCLOMETASONE INITIALLY BINDS THE CORTICOSTEROID RECEPTOR. THIS COMPLEX MIGRATES TO THE NUCLEUS WHERE IT BINDS TO DIFFERENT GLUCOCORTICOID RESP