PSORITOP 0.005% TOPICAL CREAM 20 GM

DESCRIPTION CALCIPOTRIOL (INN) OR CALCIPOTRIENE (USAN) IS A SYTHETIC DERIVATIVE OF CALCITRIOL OR VITAMIN D. INDICATION FOR THE TREATMENT OF MODERATE PLAQUE PSORIASIS IN ADULTS. MECHANISM OF ACTION THE PRECISE MECHANISM OF CALCIPOTRIOL IN REMITTING PSORIASIS IS NOT WELL-UNDERSTOOD. HOWEVER IT HAS BEEN SHOWN TO HAVE COMPARABLE AFFINITY WITH CALCITRIOL FOR THE VITAMIN D RECEPTOR WHILE BEING LESS THAN 1% AS ACTIVE AS THE CALCITRIOL IN REGULATING CALCIUM METABOLISM. THE VITAMIN D RECEPTOR (VDR) BELONGS TO THE STEROID/THYROID RECEPTOR SUPERFAMILY AND IS FOUND ON THE CELLS OF MANY DIFFERENT TISSUES INCLUDING THE THYROID BONE KINDNEY AND T CELLS OF THE IMMUNE SYSTEM. T CELLS ARE KNOWN TO PLAY A ROLE IN PSORIASIS AND IT IS THOUGHT THAT THE BINDING OF CALCIPOTRIOL TO THE VDR MODULATES THE T CELLS GENE TRANSCRIPTION OF CELL DIFFERENTIATION AND PROLIFERATION RELATED GENES.