RESTINE 20 TAB

ABOUT MECLIZINE FIRST GENERATION H1 ANTAGONIST PIPERAZINE DERIVATIVE ANTIHISTAMINE ANTIEMETIC ANTINAUSEANT. MECHANISM OF ACTION OF MECLIZINE MECLIZINE PRODUCES ANTIEMETIC ACTION BY ITS CENTRAL ACTION ON CHEMORECEPTOR TRIGGER ZONE (CTZ). IT DECREASES THE SENSITIVITY OF LABYRINTH APPARATUS WHICH TRANSMIT STIMULI TO THE CTZ AND STIMULATES THE VOMITING CENTER. MECLIZINE PRODUCES ANTIVERTIGO ACTION BY DECREASING THE EXCITABILITY OF MIDDLE EAR LABYRINTH. IT BLOCKS THE CONDUCTION IN THE MIDDLE EAR VESTIBULAR PATH WAYS. MECLIZINE IS A POTENT H1 RECEPTOR ANTIHISTAMINIC AGENT. IT HAS ANTICHOLINERGIC ACTIVITY ALSO ABOUT VIT B6 PHYSIOLOGICAL FUNCTIONS: IT IS INVOLVED AS A COENZYME (PYRIDOXAL PHOSPHATE) IN METABOLISM OF TRYPTOPHAN IN SEVERAL METABOLIC TRANSFORMATIONS OF AMINO ACIDS INCLUDING TRANSAMINATION DECARBOXYLATION & RACEMIZATION. DEFICIENCY SYMPTOMS: PERIPHERAL NEURITIS SEIZURES STOMATITIS GLOSSITIS ANAEMIA SEBORRHEA LIKE LESIONS.