RIFAMPIN 300MG 10 CAPS. (DEBEIKY)

About Rifampicin Rifamycin derivative Antituberculosis antibiotic. Mechanism of Action of Rifampicin Rifampicin is primarily bactericidal and has some bacteriostatic properties also. It acts by inhibiting DNA dependent RNA polymerase and thus stopping the expression of bacterial genes.M.tuberculosis requires DNA dependent RNA polymerase enzyme for the synthesis of RNA and protein. Without this enzyme bacteria cannot reproduce and they die. Indications for Rifampicin 1. Leprosy 2. Tuberculosis 3. Prophylaxis of meningococcal carriers 4. Prophylaxis of H. influenzae Interactions for Rifampicin Rifampicin by inducing the hepatic microsomal enzymes may reduce the efficacy of the following drugs: Acetaminophen oral anticoagulants barbiturates benzodiazepines chloramphenicol clofibrate. Oral contraceptives corticosteroids cyclosporine digitoxin disopyramide beta blockers oestrogens hydantoins mexiletine quinidine sulfones sulphonylureas theophylline verapamil