ATRABESYLATE 50 MG I.V. INJ. & INF. 5 AMPS

INDICATION FOR USE AS AN ADJUNCT TO GENERAL ANESTHESIA TO FACILITATE ENDOTRACHEAL INTUBATION AND TO PROVIDE SKELETAL MUSCLE RELAXATION DURING SURGERY OR MECHANICAL VENTILATION. PHARMACODYNAMICS ATRACURIUM IS A NONDEPOLARIZING SKELETAL MUSCLE RELAXANT. ATRACURIUM CAN BE USED MOST ADVANTAGEOUSLY IF MUSCLE TWITCH RESPONSE TO PERIPHERAL NERVE STIMULATION IS MONITORED TO ASSESS DEGREE OF MUSCLE RELAXATION. THE DURATION OF NEUROMUSCULAR BLOCK PRODUCED BY ATRACURIUM IS APPROXIMATELY ONE THIRD TO ONE HALF THE DURATION OF BLOCK BY D-TUBOCURARINE METOCURINE AND PANCURONIUM AT INITIALLY EQUIPOTENT DOSES. AS WITH OTHER NONDEPOLARIZING NEUROMUSCULAR BLOCKERS THE TIME TO ONSET OF PARALYSIS DECREASES AND THE DURATION OF MAXIMUM EFFECT INCREASES WITH INCREASING DOSES OF ATRACURIUM. REPEATED ADMINISTRATION OF MAINTENANCE DOSES OF ATRACURIUM HAS NO CUMULATIVE EFFECT ON THE DURATION OF NEUROMUSCULAR BLOCK IF RECOVERY IS ALLOWED TO BEGIN PRIOR TO REPEAT DOSING.