SANDIMMUN NEORAL 100 MG/ML ORAL SOL. 50 ML
سعر SANDIMMUN NEORAL 100 MG/ML ORAL SOL. 50 ML
700.00 جنية
الشركة المنتجة لـ SANDIMMUN NEORAL 100 MG/ML ORAL SOL. 50 ML
NOVARTIS
المادة الفعالة SANDIMMUN NEORAL 100 MG/ML ORAL SOL. 50 ML
CYCLOSPORIN
معلومات عن SANDIMMUN NEORAL 100 MG/ML ORAL SOL. 50 ML
About Cyclosporin A
A cyclic nonribosomal peptide(11 amino acids) immunosuppressant drug Organ transplant rejection prevention.
Mechanism of Action of Cyclosporin A
Cyclosporine binds to the cytosolic protein cyclophilin (immunophilin) of immunocompetent lymphocytes especially T-lymphocytes. This complex inhibits calcineurin which is responsible for activating the transcription of interleukin 2. It also inhibits lymphokine production and interleukin release and therefore leads to reduced function of effecter T-cells. Drug prevents mitochondrial PT pore from opening and inhibits cytochrome C release and also apoptosis induced by it.
Indications for Cyclosporin A
1. Organ transplant rejection
2. Rheumatoid arthritis
3. Crohn`s syndrome
4. Nephrotic syndrome
5. Psoriasis
6. Ulcerative colitis
7. Uveitis
8. Neuroprotection in traumatic brain injury
9. Aplastic anemia
10. Myasthenia gravis
11. Dermatomyositis
