SCABINE 0.3% CREAM 20 GM

INDICATION FOR THE TREATMENT OF PATIENTS INFESTED WITH SARCOPTES SCABIEI OR PEDICULOSIS CAPITIS WHO HAVE EITHER FAILED TO RESPOND TO ADEQUATE DOSES OR ARE INTOLERANT OF OTHER APPROVED THERAPIES. MECHANISM OF ACTION LINDANE IS AN ORGANOCHLORIDE INSECTICIDE THAT HAS SIMILAR NEUROTOXIC PROTPERTIES TO DDT. IT EXERTS ITS PARASITICIDAL ACTION BY BEING DIRECTLY ABSORBED THROUGH THE PARASITE S EXOSKELETON (PRIMARILY LICE OR SCABIES) AND THEIR OVA. THE GAMMA-AMINOBUTYRIC ACID (GABA(1)) RECEPTOR/CHLORIDE IONOPHORE COMPLEX IS THE PRIMARY SITE OF ACTION FOR LINDANE AND OTHER INSECTICIDES SUCH AS ENDOSULFAN AND FIPRONIL. BLOCKAGE OF THE GABA-GATED CHLORIDE CHANNEL REDUCES NEURONAL INHIBITION WHICH LEADS TO HYPEREXCITATION OF THE CENTRAL NERVOUS SYSTEM. THIS RESULTS IN PARALYSIS CONVULSIONS AND DEATH. LINDANE HAS VERY LOW OVICIDAL ACTIVITY.