SELOKENZOC 50 MG 28 PROLONGED R.TABS

Description Metoprolol is a cardioselective beta1-adrenergic blocking agent used for acute myocardial infarction (MI) heart failure angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The beta1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses metoprolol selectively blocks cardiac beta1-adrenergic receptors with little activity against beta2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity.