SPIRAZOLE 20 TAB

PREGNANCY RELATED INFORMATION USE WITH CAUTION. BREAST FEEDING RELATED INFORMATION CONTRAINDICATED INDICATIONS FOR METRONIDAZOLE + SPIRAMYCIN 1.DENTAL ABSCESS 2.CELLULITES OF THE JAW 3.PERICORONITIS 4.GINGIVITIS 5.STOMATITIS 6.PAROTITIS 7.SUBMAXILLARITIS 8.PREVENTION OF LOCAL POST-OP INFECTIOUS COMPLICATIONS FOLLOWING DENTAL & ORAL SURGERY ABOUT METRONIDAZOLE A NITROIMIDAZOLE ANTIBIOTIC ANTI-INFECTIVE ANTIPROTOZOAL AMEBICIDE. MECHANISM OF ACTION OF METRONIDAZOLE METRONIDAZOLE IS NITRO IMIDAZOLES WHICH HAVE BROAD SPECTRUM CIDAL ACTIVITY AGAINST PROTOZOA AND SOME ANAEROBIC BACTERIA. ITS SELECTIVE TOXICITY TO ANAEROBIC MICROBES INVOLVES 1. DRUG ENTERS THE CELL BY DIFFUSION 2. NITRO GROUP OF DRUG IS REDUCED BY REDOX PROTEINS PRESENT ONLY IN ANAEROBIC ORGANISMS TO REACTIVE NITRO RADICAL WHICH EXERTS CYTOTOXIC ACTION BY DAMAGING DNA AND OTHER CRITICAL BIOMOLECULES. 3. DNA HELIX DESTABILIZATION & STRAND BREAKAGE HAS BEEN OBSERVED.