TARGOMASH 80MG 30 F.C. TABS

ABOUT VALSARTAN ANGIOTENSIN II RECEPTOR ANTAGONIST ANTIHYPERTENSIVE. MECHANISM OF ACTION OF VALSARTAN IT IS A COMPETITIVE ANTAGONIST OF ANGIOTENSIN-2 AT AT-1 RECEPTOR. IT DECREASES PERIPHERAL RESISTANCE AND LOWERS BP IN HYPERTENSIVE INDIVIDUALS. IT BLOCKS ALL OVERT ACTIONS OF ANGIOTENSIN-2 SUCH AS: - 1. VASOCONSTRICTION 2. CENTRAL & PERIPHERAL SYMPATHETIC STIMULUS 3. RELEASE OF ALDOSTERONE AND ADRENALINE 4. SALT AND WATER REABSORPTION 5. CENTRAL ACTIONS LIKE THIRST VASOPRESSIN RELEASE AND GROWTH PROMOTING ACTIONS ON HEART AND BLOOD VESSELS. INDICATIONS FOR VALSARTAN 1. HYPERTENSION INTERACTIONS FOR VALSARTAN POTASSIUM-SPARING DIURETICS (E.G. SPIRONOLACTONE TRIAMTERENE AMILORIDE) POTASSIUM SUPPLEMENTS OR SALT SUBSTITUTES CONTAINING POTASSIUM: CONCOMITANT USE OF VALSARTAN WITH THESE DRUGS WILL RESULT IN HYPERKALAEMIA AND IN HEART FAILURE PATIENTS IT INCREASES SERUM CREATININE.