THIOPENTAL SODIUM-T3A 1GM IV VIAL U.S.P.23

INDICATION FOR USE AS THE SOLE ANESTHETIC AGENT FOR BRIEF (15 MINUTE) PROCEDURES FOR INDUCTION OF ANESTHESIA PRIOR TO ADMINISTRATION OF OTHER ANESTHETIC AGENTS TO SUPPLEMENT REGIONAL ANESTHESIA TO PROVIDE HYPNOSIS DURING BALANCED ANESTHESIA WITH OTHER AGENTS FOR ANALGESIA OR MUSCLE RELAXATION FOR THE CONTROL OF CONVULSIVE STATES DURING OR FOLLOWING INHALATION ANESTHESIA OR LOCAL ANESTHESIA IN NEUROSURGICAL PATIENTS WITH INCREASED INTRACRANIAL PRESSURE AND FOR NARCOANALYSIS AND NARCOSYNTHESIS IN PSYCHIATRIC DISORDERS. MECHANISM OF ACTION THIOPENTAL BINDS AT A DISTINCT BINDING SITE ASSOCIATED WITH A CL- IONOPORE AT THE GABAA RECEPTOR INCREASING THE DURATION OF TIME FOR WHICH THE CL- IONOPORE IS OPEN. THE POST-SYNAPTIC INHIBITORY EFFECT OF GABA IN THE THALAMUS IS THEREFORE PROLONGED.