THROMBONORM 0.5MG 100CAPS

Indication: For the treatment of patients with thrombocythemia secondary to myeloproliferative disorders to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events. dosage: Adult- The recommended starting dose is 0.5 mg qid or 1 mg bid (2 capsules of 0.5 mg twice a day) and can be increased to 4 times daily. Mechanism of action : The mechanism by which anagrelide reduces blood platelet count is still under investigation. Studies in patients support a hypothesis of dose-related reduction in platelet production resulting from a decrease in megakaryocyte hypermaturation. In blood withdrawn from normal volunteers treated with anagrelide a disruption was found in the postmitotic phase of megakaryocyte development and a reduction in megakaryocyte size and ploidy.