THYROXINE 50MCG 100 TAB

Indication For use alone or in combination with antithyroid agents to treat hypothyroidism goiter chronic lymphocytic thyroiditis myxedema coma and stupor. Mechanism of action Levothyroxine acts like the endogenous thyroid hormone thyroxine (T4 a tetra-iodinated tyrosine derivative). In the liver and kidney T4 is converted to T3 the active metabolite. In order to increase solubility the thyroid hormones attach to thyroid hormone binding proteins thyroxin-binding globulin and thyroxin-binding prealbumin (transthyretin). Transport and binding to thyroid hormone receptors in the cytoplasm and nucleus then takes place. Thus by acting as a replacement for natural thyroxine symptoms of thyroxine deficiency are relieved.