TICLOPIDINE 250MG 10 F.C.TAB

ABOUT TICLOPIDINE THIENOPYRIDINE DERIVATIVE AN ADENOSINE DIPHOSPHATE (ADP) RECEPTOR INHIBITOR ANTIPLATELET AGENT. MECHANISM OF ACTION OF TICLOPIDINE THE DRUG EXERTS IT`S ANTITHROMBOTIC ACTION BY INTERFERING WITH PLATELET AGGREGATION. IT ALTERS SURFACE RECEPTORS IN PLATELETS AND INHIBITS ADP AND FIBRINOGEN INDUCED PLATELET-FIBRINOGEN AND PLATELET-PLATELET BINDING AND PREVENTS PLATELET AGGREGATION. IT BLOCKS G-PROTEIN COUPLED P2YAC TYPE OF INHIBITORY PURINERGIC RECEPTORS WHICH MEDIATES ADENYLYL CYCLASE INHIBITION BY ADP. IT PROLONGS BLEEDING TIME. INTERACTIONS FOR TICLOPIDINE ANTACIDS: ABSORPTION OF TICLOPIDINE DECREASED. CIMETIDINE: CHRONIC CIMETIDINE ADMINISTRATION RESULTS IN DECREASED CLEARANCE OF TICLOPIDINE. ASPIRIN: EFFECT OF ASPIRIN ON COLLAGEN INDUCED PLATELET AGGREGATION POTENTIATED HENCE COADMINISTATION NOT RECOMMENDED. DIGOXIN: DIGOXIN LEVELS MAY BE SLIGHTLY DECREASED. THEOPHYLLINE: ELIMINATION HALF LIFE OF THEOPHYLLINE INCREASED SIGNIFICANTLY.