VENTOBRONCHAL PLUS 20 TAB

INDICATION FOR RELIEF OF ACUTE BRONCHIAL ASTHMA AND FOR REVERSIBLE BRONCHOSPASM ASSOCIATED WITH CHRONIC BRONCHITIS AND EMPHYSEMA. PHARMACODYNAMICS DYPHYLLINE A XANTHINE DERIVATIVE IS A BRONCHODILATOR USED FOR RELIEF OF ACUTE BRONCHIAL ASTHMA AND FOR REVERSIBLE BRONCHOSPASM ASSOCIATED WITH CHRONIC BRONCHITIS AND EMPHYSEMA. DYPHYLLINE IS A XANTHINE DERIVATIVE WITH PHARMACOLOGIC ACTIONS SIMILAR TO THEOPHYLLINE AND OTHER MEMBERS OF THIS CLASS OF DRUGS. ITS PRIMARY ACTION IS THAT OF BRONCHODILATION BUT IT ALSO EXHIBITS PERIPHERAL VASODILATORY AND OTHER SMOOTH MUSCLE RELAXANT ACTIVITY TO A LESSER DEGREE. MECHANISM OF ACTION THE BRONCHODILATORY ACTION OF DYPHYLLINE AS WITH OTHER XANTHINES IS THOUGHT TO BE MEDIATED THROUGH COMPETITIVE INHIBITION OF PHOSPHODIESTERASE WITH A RESULTING INCREASE IN CYCLIC AMP PRODUCING RELAXATION OF BRONCHIAL SMOOTH MUSCLE AS WELL AS ANTAGONISM OF ADENOSINE RECEPTORS.