VINRACINE 1MG/ML (1MG) VIAL

سعر VINRACINE 1MG/ML (1MG) VIAL
28.80 جنية
الشركة المنتجة لـ VINRACINE 1MG/ML (1MG) VIAL
HIKMA SPECIALIZED PHARMACEUTICALS
المادة الفعالة VINRACINE 1MG/ML (1MG) VIAL
VINCRISTINE
معلومات عن VINRACINE 1MG/ML (1MG) VIAL
About Vincristine
Natural (Vinca) Alkaloid a mitotic inhibitor Antineoplastic.
Mechanism of Action of Vincristine
Vincristine binds to the tubuline dimers (tubuline is a structural protein which polymerizes to form microtubules) and inhibit the polymerization causing disassembly of microtubule structure. Disruption of the microtubules arrests mitosis in metaphase. It also inhibits DNA-dependant RNA synthesis and purine synthesis.
Interactions for Vincristine
Digoxin: Decreased plasma digoxin levels and renal excretion.
L-asparaginase: Hepatic clearance of vincristine is reduced if L-asparaginase is administered first. Thus to minimise toxicity vincristine should be given 12 to 24 hours before administering L- asparaginase.
Mitomycin-C: Acute pulmonary reaction may occur.
Phenytoin: Reduced phenytoin plasma levels.
أدوية مشابهة

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