BETASOTAL 80 MG 10 TAB

ABOUT SOTALOL BETA (NONSELECTIVE) ADNEREGIC BLOCKING AGENT A POTASSIUM CHANNEL BLOCKER ANTI-HYPERTENSIVE CLASS III ANTI-ARRHYTHMIC. MECHANISM OF ACTION OF SOTALOL SOTALOL IS A NON SELECTIVE BETA RECEPTOR ANTAGONIST. IT HAS NEGATIVE CHRONOTROPIC EFFECT ON HEART. IT DECREASES OXYGEN CONSUMPTION; CARDIAC WORK AND AORTIC PRESSURE. IT INCREASES OXYGEN SUPPLY AND EXERCISE TOLERANCE IN ANGINA PATIENTS. IT PROLONGS DURATION OF MONOPHASIC ACTION POTENTIALS IN ATRIA AND VENTRICLES &. PROLONGS EFFECTIVE REFRACTORY PERIOD OF AV NODE HIS PURKINJE SYSTEM AND ALL CARDIAC TISSUES AND AV CONDUCTION IS DELAYED. IT HAS CLASS 3 ANTIARRHYTHMIC ACTION OF PROLONGING REPOLARISATION BY BLOCKING CARDIAC K+ CHANNELS. IT INCREASES VENTRICULAR FIBRILLATION THRESHOLD IN MYOCARDIUM THE DRUG DECREASES BP IN HYPERTENSIVE INDIVIDUALS. INITIALLY TOTAL PERIPHERAL RESISTANCE INCREASES DUE TO BLOCKADE OF BETA MEDIATED VASODILATATION AND DECREASE IN CARDIAC OUTPUT; SO LITTLE CHANGE IN BP.