ADCOCYCLINE 3% OINT. 15 GM

ABOUT TETRACYCLINE A BROAD-SPECTRUM POLYKETIDE ANTIBIOTIC TETRACYCLINE DERIVATIVE. MECHANISM OF ACTION OF TETRACYCLINE TETRACYCLINE IS A BROAD SPECTRUM ANTIBIOTIC WHICH HAS MORE SPECIFIC ACTION AGAINST GRAM POSITIVE ORGANISMS THAN GRAM NEGATIVE ORGANISMS. IT EXERTS ITS BACTERIOSTATIC ACTION BY ACCUMULATING INSIDE THE BACTERIA THROUGH SPECIFIC TRANSPORTER PROTEIN & INHIBITS BACTERIAL PROTEIN SYNTHESIS BY ATTACHING TO 30 S SUBUNIT OF BACTERIAL RIBOSOME (WHICH ARE ABSENT IN MAMMALS). IT CHELATES CATIONS LIKE CA &MG AND INHIBITS FUNCTIONING OF VARIOUS ENZYMES & RIBOSOME. IT IS USED IN SOME AREAS FOR THE TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA