ADCOKION 10MG/ML 5 AMP. FOR I.M. INJ

ABOUT VITAMIN K FAT SOLUBLE VITAMIN ANTIHEMORRHAGIC. MECHANISM OF ACTION OF VITAMIN K PHYTONADIONE (VITAMIN K1) IS A SYNTHETIC FORM OF VITAMIN K AND IS LIPID SOLUBLE. VITAMIN K ACTS AS A COFACTOR IN THE SYNTHESIS OF COAGULATION PROTEINS; PROTHROMBIN FACTORS VII IX AND X BY LIVER. VITAMIN K DEPENDENT CHANGES IN THE FINAL STAGE OF SYNTHESIS OF THESE COAGULATION PROTEINS IS GAMA-CARBOXYLATION OF GLUTAMATE RESIDUES OF THESE ZYMOGEN PROTEINS AND THEIR DESCARBOXY-FORMS CONVERTED IN TO ACTIVE FORMS; WHICH CONFERS ON THEM THE CAPACITY TO BIND CA2+ AND TO GET BOUND TO THE PHOSPHOLIPID SURFACES WHICH ARE ESSENTIAL PROPERTIES FOR PARTICIPATION IN THE COAGULATION CASCADE.