ADRENOCORTINE 1MG/ML I.M. AMP

TETRACOSACTIDE ACETATE CONSISTS OF THE FIRST 24 AMINO ACIDS OCCURRING IN THE NATURAL CORTICOTROPIC HORMONE (ACTH) SEQUENCE AND DISPLAYS THE SAME PHYSIOLOGICAL PROPERTIES AS ACTH. IN THE ADRENAL CORTEX IT STIMULATES THE BIOSYNTHESIS OF GLUCOCORTICOIDS MINERALOCORTICOIDS AND TO A LESSER EXTENT ANDROGENS WHICH EXPLAINS ITS THERAPEUTIC EFFECT IN CONDITIONS RESPONSIVE TO GLUCOCORTICOID TREATMENT. - THERAPEUTIC USE: SYNACTHEN DEPOT SHOULD NORMALLY ONLY BE USED FOR SHORT-TERM THERAPY IN CONDITIONS FOR WHICH GLUCOCORTICOIDS ARE INDICATED IN PRINCIPLE FOR EXAMPLE IN ULCERATIVE COLITIS AND CROHN S DISEASE JUVENILE RHEUMATOID ARTHRITIS OR AS ADJUNCT THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS AND OSTEOARTHROSIS. SYNACTHEN DEPOT MAY BE PARTICULARLY USEFUL IN PATIENTS UNABLE TO TOLERATE ORAL GLUCOCORTICOID THERAPY OR IN PATIENTS WHERE NORMAL THERAPEUTIC DOSES OF GLUCOCORTICOIDS HAVE BEEN INEFFECTIVE. - DIAGNOSTIC USE: AS A DIAGNOSTIC AID FOR THE INVESTIGATION OF ADRENOCORTICAL INSUFFICIENCY.