CELEBORG 200 MG 20 CAPS

ABOUT CELECOXIB NON-STEROIDAL ANTI INFLAMMATORY DRUG (NSAID) COX-2 SELECTIVE INHIBITOR ANTI-INFLAMMATORY AGENT. MECHANISM OF ACTION OF CELECOXIB THIS INHIBITS PROSTAGLANDIN SYNTHESIS PERIPHERALLY BY SELECTIVE NONCOMPETITIVE INHIBITION OF CYCLOOXYGENASE-2 (COX-2) ENZYME. IT BINDS WITH ITS POLAR SULFONAMIDE SIDE CHAIN TO A HYDROPHILIC SIDE POCKET REGION CLOSE TO THE ACTIVE COX-2 BINDING SITE (BOTH COX-1 AND COX-2 CATALYZE THE CONVERSION OF ARACHIDONIC ACID TO PROSTAGLANDIN (PG) H2 THE PRECURSOR OF PGS AND THROMBOXANE). THIS RESULTS ITS ANTI-INFLAMMATORY ACTION INDICATIONS FOR CELECOXIB 1. OSTEOARTHRITIS 2. RHEUMATOID ARTHRITIS 3. ACUTE GOUT CONTRA-INDICATIONS OF CELECOXIB 1. HYPERSENSITIVITY TO CELECOXIB 2. ALLERGIC TYPE REACTIONS TO SULPHONAMIDES /ASPIRIN OR OTHER NSAIDS.