CHRONSALBUTAM INHALER 50 MCG/DOSE 200 DOSES

About Levosalbutamol Beta2-Adrenergic Agonist Phenethylamine derivative Bronchodilator(Antiasthma) uterine relaxant. Mechanism of Action of Levosalbutamol Salbutamol is a short acting BETA-2 receptor agonist. It selectively stimulates BETA-2 receptors present in airway Uterus and Vascular Smooth muscles. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of BETA-2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. BETA-2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles. BETA-2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production.