CLOZAPEX 25 MG 50 TAB

ABOUT CLOZAPINE DIBENZODIAZEPINE DERIVATIVE ATYPICAL ANTIPSYCHOTIC TRANQUILIZER ANTI-PSYCHOTIC. MECHANISM OF ACTION OF CLOZAPINE CLOZAPINE BINDS TO DOPAMINE RECEPTORS. IT HAS MORE AFFINITY TOWARDS D4 RECEPTOR THAN OTHER DOPAMINE RECEPTORS I.E.D1 D2 D3 &D5 RECEPTORS. IT EXERTS ITS ANTIPSYCHOTIC ACTIVITY BY BLOCKING THE DOPAMINE PROJECTIONS IN THE LIMBIC SYSTEM. IT ACTS AS A COMPETITIVE DOPAMINE ANTAGONIST. CLOZAPINE ALSO PRODUCES ALPHA ADRENERGIC BLOCKING ACTIVITY ANTI-SEROTONIN ACTIVITY AND ANTICHOLINERGIC ACTIVITY. IT ALSO PRODUCES MODERATELY POTENT ANTICHOLINERGIC BUT PARADOXICALLY INDUCE SALIVATION AND H1 BLOCKING ACTIVITY. INTERACTIONS FOR CLOZAPINE ANTICHOLINERGICS: ANTICHOLINERGIC EFFECTS MAY BE POTENTIATED. ANTIHYPERTENSIVES: HYPOTENSIVE EFFECTS MAY BE POTENTIATED. CNS DRUGS: CAUTION IS ADVISED WITH CONCOMITANT USE. AGENTS THAT SUPPRESS BONE MARROW FUNCTION: AVOID CONCOMITANT USE.