COLOSALAZINE-EC 500 MG 20 E.C.TABS

ABOUT SULPHASALAZINE COMPOSED OF 5-AMINOSALICYLIC ACID AND SULFAPYRIDINE ANTI-INFECTIVE (IN INFLAMMATORY BOWEL DISEASE) ANTI ARTHRITIC. MECHANISM OF ACTION OF SULPHASALAZINE SULFASALAZINE EXERTS ITS ANTI-INFLAMMATORY ACTION BY INHIBITING LIPOXYGENASE ENZYME. THIS WILL LEADS TO DECREASED PRODUCTION OF PRO-INFLAMMATORY LEUKOTRIENES (LTB4) AND 5-HYDROXY EICOSA TETRA ENOIC ACIDS (HETE) IN THE INTESTINAL WALL. IT INHIBITS THE PRODUCTION OF INFLAMMATORY MEDIATORS LIKE INTERLEUKIN-1 TUMOR NECROSIS FACTOR-ALPHA ETC INDICATIONS FOR SULPHASALAZINE 1. ULCERATIVE COLITIS 2. CROHN`S DISEASE 3. RHEUMATOID ARTHRITIS 4. DIARRHEA INTERACTIONS FOR SULPHASALAZINE FOLIC ACID : SIGNS OF FOLIC DEFICIENCY WITH SULPHASALAZINE. DIGOXIN : POSSIBLY REDUCED EFFICACY OF DIGOXIN.