DESFERAL 500MG 10 VIALS

About DEFEROXAMINE Antidote Natural product from Streptomyces pilosus An iron-Chelating Agent anti-oxidant. Mechanism of Action of DEFEROXAMINE DEFEROXAMINE is a chelating agent. The chelating agents being antagonists compete with body ligands for the heavy metals. They usually have 2 or more reacting groups which can hold the metal from 2 sides to form a ring. These should have higher affinity for the toxic metal to be excreted than Ca 2+ which is readily available in plasma than in body fluids. They should also have higher affinity for the metal than the body ligands. DEFEROXAMINE (3 hydroxy group) binds to ferric iron and preventing entering in to the further chemical reactions and forms water soluble iron complex and easily excreted in the urine and bile. It can also form chelating complex with aluminium and therefore used in the treatment of aluminium overload.