DICLONERVE 30 CAPS

MECHANISM OF ACTION OF DICLOFENAC SODIUM DICLOFENAC POSSESS ANALGESIC ANTI-INFLAMMATORY AND ANTIPYRETIC ACTION. IT INHIBITS THE ENZYME CYCLO-OXYGENASE AND THERE BY INHIBITS THE SYNTHESIS OF PROSTAGLANDINS (PGS). IT IS MORE POTENT AGAINST CYCLO-OXYGENASE-2 ENZYME AS COMPARED TO OTHER NSAIDS LIKE INDOMETHACIN NAPROXEN ETC. IT REDUCES INTRACELLULAR CONCENTRATIONS OF FREE ARACHIDONIC ACID IN LEUKOCYTE BY ALTERING ITS RELEASE OR UPTAKE. . PHARMACOKINETS OF DICLOFENAC SODIUM ABSORPTION: DICLOFENAC SODIUM IS RAPIDLY ABSORBED AFTER ORAL ADMINISTRATION. IT UNDERGOES FIRST PASS METABOLISM AND ITS BIOAVAILABILITY IS 50 % ONLY. DISTRIBUTION: IT IS DISTRIBUTED IN HIGHLY PROTEIN BOUND FORM. METABOLISM: DICLOFENAC SODIUM IS METABOLISED IN THE LIVER. EXCRETION: DRUG AND METABOLITES ARE PRIMARILY EXCRETED IN URINE AND SOME AMOUNT IN THE BILE.