DILOZOLE 20 TAB

About Diloxanide Furoate Dichloroacetamide derivative anti-protozoal Luminal amebicides. Mechanism of Action of Diloxanide Furoate Diloxanide Furoate is a dicloroacetamide derivative which acts as a luminal amoebicide. It exerts its action by directly killing the trophozoites responsible for production of cysts. Indications for Diloxanide Furoate 1. Mild intestinal Amoebiasis 2. Asymptomatic cyst passers of Entamoeba histolitica Mechanism of action Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then covalently binds to DNA disrupt its helical structure inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.