ALKAPRESS 5MG 20 TAB

ABOUT AMLODIPINE CALCIUM CHANNEL BLOCKER ANTI HYPERTENSIVE ANTI ANGINA. MECHANISM OF ACTION OF AMLODIPINE AMLODIPINE IS A SECOND GENERATION DIHYDROPYRIDINE CA CHANNEL BLOCKER. IT EXERTS IT`S ANTIHYPERTENSIVE ANTIANGINAL ACTIONS THROUGH BLOCKING THE INFLUX OF CA IONS THROUGH VOLTAGE GATED L-TYPE CA CHANNELS TO THE PERIPHERAL VASCULAR SMOOTH MUSCLE CELLS CORONARY SMOOTH MUSCLE CELLS AND TO THE MYOCARDIAL CELLS. THUS CAUSES DILATATION OF VASCULAR ENDOTHELIUM DECREASE PERIPHERAL RESISTANCE & REDUCE MYOCARDIAL OXYGEN DEMAND .IT MARKEDLY RELAX ARTERIOLES AND MILDER EFFECTS ON VEINS. THEY DO NOT COMPROMISE HAEMODYNAMICS AND CEREBRAL AND RENAL PERFUSION. INDICATIONS FOR AMLODIPINE 1.HYPERTENSION 2.PRINZMETAL`S ANGINA 3.STABLE ANGINA