EMEDROTEC 3MG 20 BUCCAL BIOADHESIVE TAB

About Prochlorperazine First-Generation Antipsychotic Phenothiazine derivative Antiemetic Antipsychotic anxiolytic. Mechanism of Action of Prochlorperazine Antipsychotic action: Prochlorperazine binds to the dopamine receptor (D1 D2 D3 &D4).It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. Peripherally and centrally it acts as a competitive Dopamine antagonist. Prochlorperazine also produces alpha adrenergic blocking activity and anticholinergic activity. It also produces weak H1 antihistaminic activity and anti serotonin activity. Antiemetic action: Antiemetic activity is by blocking dopamine receptor (D2 receptor) in the Chemoreceptor trigger zone (CTZ) Migraine: Prochlorperazine has been used in migraine to control severe nausea and vomiting unresponsive to Antiemetics and to relieve the pain of severe migraine attacks unresponsive to parenteral Dihydroergotamine or Sumatriptan.