ALLERZONE 0.1% OINT. 25 GM

ABOUT MOMETASONE A GLUCOCORTICOID STEROID ANTI PSORIATIC ANTI ASTHMA ANTI INFLAMMATORY. MECHANISM OF ACTION OF MOMETASONE MOMETASONE IS A TOPICAL MEDIUM POTENCY GLUCOCORTICOID. THE DRUG EXERTS ITS PHARMACOLOGICAL ACTION BY PENETRATING AND BINDING TO CYTOPLASMIC RECEPTOR PROTEIN AND CAUSES A STRUCTURAL CHANGE IN STEROID RECEPTOR COMPLEX. THIS STRUCTURAL CHANGE ALLOWS IT`S MIGRATION IN TO THE NUCLEUS AND THEN BINDING TO SPECIFIC SITES ON THE DNA WHICH LEADS TO TRANSCRIPTION OF SPECIFIC M-RNA AND WHICH ULTIMATELY REGULATES PROTEIN SYNTHESIS. IT EXERTS HIGHLY SELECTIVE GLUCOCORTICOID ACTION. IT STIMULATES THE ENZYMES NEEDED TO DECREASE THE INFLAMMATORY RESPONSE. THE DRUG EXERTS ANTI-INFLAMMATORY AND IMMUNOSUPPRESSANT ACTIONS AS FOLLOWS: - 1) INDUCE LIPOCORTINS IN MACROPHAGES ENDOTHELIUM AND FIBROBLASTS WHICH INHIBITS PHOSPHOLIPASE A2 AND THUS DECREASES THE PRODUCTION OF PROSTAGLANDINS LEUKOTRIENES (LT) AND PLATELET ACTIVATING FACTOR