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About Buspirone Psychotropic drug serotonin 5-HT1A receptor partial agonist weak Dopamine (D2) antagonist azaspirodecanediones derivative Sedative anxiolytic agent. Mechanism of Action of Buspirone Buspirone has a partial agonistic action on 5HT1A receptor and it stimulates presynaptic autoreceptors. This will produce a decrease in serotonin neuronal activity. It also has antagonistic action on post synaptic 5HT1A receptor. Buspirone has a weak Dopamine (D2) antagonistic action. Mood elevation may be due to facilitation of noradrenergic system. Indications for Buspirone Anxiety Typical Dosage for Buspirone Adult: 15 - 30 mg / day in 3 divided dose Initial dose: 15 mg / day in 3 divided dose. Dose can be gradually increased in every 3 days. Maximum daily dose: 60 mg / day