FERRIPROX 100MG/ML (250ML) ORAL SOLUTION

DESCRIPTION DEFERIPRONE IS AN ORAL IRON CHELATOR USED AS A SECOND LINE AGENT IN THALASSEMIA SYNDROMES WHEN IRON OVERLOAD FROM BLOOD TRANSFUSIONS OCCURS. THALASSEMIAS ARE A TYPE OF HEREDITARY ANAEMIA DUE A DEFECT IN THE PRODUCTION OF HEMOGLOBIN. AS A RESULT ERYTHROPOIESIS THE PRODUCTION OF NEW RED BLOOD CELLS IS IMPAIRED. FDA APPROVED ON OCTOBER 14 2011. INDICATION : DEFERIPRONE IS INDICATED IN THALASSEMIA SYNDROMES WHEN FIRST LINE CHELATION AGENTS ARE NOT ADEQUATE TO TREAT TRANSFUSIONAL IRON OVERLOAD. MECHANISM OF ACTION DEFERIPRONE " IS AN IRON CHELATOR THAT BINDS TO FERRIC IONS (IRON III) AND FORMS A 3:1 (DEFERIPRONE:IRON) STABLE COMPLEX AND IS THEN ELIMINATED IN THE URINE. DEFERIPRONE IS MORE SELECTIVE FOR IRON IN WHICH OTHER METALS SUCH AS ZINC COPPER AND ALUMINUM HAVE A LOWER AFFINITY FOR DEFERIPRONE.