FLECTOR EP 1.3% TISSUGEL 5 PATCHES

EACH ADHESIVE FLECTOR TOPICAL SYSTEM CONTAINS 180 MG OF DICLOFENAC EPOLAMINE. A NON-STEROIDAL ANTI-INFLAMMATORY AGENT (NSAID) WITH ANTIPYRETIC AND ANALGESIC ACTIONS. INDICATION FOR THE ACUTE AND CHRONIC TREATMENT OF SIGNS AND SYMPTOMS OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS. MECHANISM OF ACTION THE ANTIINFLAMMATORY EFFECTS OF DICLOFENAC ARE BELIEVED TO BE DUE TO INHIBITION OF BOTH LEUKOCYTE MIGRATION AND THE ENZYME CYLOOXYGENASE (COX-1 AND COX-2) LEADING TO THE PERIPHERAL INHIBITION OF PROSTAGLANDIN SYNTHESIS. AS PROSTAGLANDINS SENSITIZE PAIN RECEPTORS INHIBITION OF THEIR SYNTHESIS IS RESPONSIBLE FOR THE ANALGESIC EFFECTS OF DICLOFENAC. ANTIPYRETIC EFFECTS MAY BE DUE TO ACTION ON THE HYPOTHALAMUS RESULTING IN PERIPHERAL DILATION INCREASED CUTANEOUS BLOOD FLOW AND SUBSEQUENT HEAT DISSIPATION. RECOMMENDED DOSAGE: ADULTS: THE USUAL DOSE REGIMEN IS 1 OR 2 PATCHES PER DAY (IE ONE APPLICATION EVERY 12 OR 24 HOURS) FOR UP TO 14 DAYS.