FOLONE 5MG 5 OILY AMPS

Description Generally refers to the 17-beta-isomer of estradiol an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized. Mechanism of action Estradiol enters target cells freely (e.g. female organs breasts hypothalamus pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA.