FROSITOR 10 MG 20 F.C. TABS
سعر FROSITOR 10 MG 20 F.C. TABS
75.00 جنية
الشركة المنتجة لـ FROSITOR 10 MG 20 F.C. TABS
FUTURE PHARMACEUTICAL INDUSTRIES (FPI) > TABUK PHARMA
المادة الفعالة FROSITOR 10 MG 20 F.C. TABS
ROSUVASTATIN
معلومات عن FROSITOR 10 MG 20 F.C. TABS
About Rosuvastatin
Statin HMG-CoA Reductase Inhibitor Antilipemic.
Mechanism of Action of Rosuvastatin
It is a hypolipidaemic statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels.