FUNGICAN 150 MG 2 CAPS

ABOUT FLUCONAZOLE A TRIAZOLE DERIVATIVE A BOARD RANGE ANTIFUNGAL. MECHANISM OF ACTION OF FLUCONAZOLE FLUCONAZOLE IS FUNGICIDAL OR FUNGISTATIC DEPENDING ON THE DRUG CONCENTRATIONS. I T INHIBITS THE CONVERSION OF LANOSTEROL TO 14 DEMETHYL LANOSTEROL BY INHIBITING THE CYTOCHROMEP450 ENZYME 14 ALPHA DEMETHYLASE AND IMPAIR ERGOSTEROL SYNTHESIS INTERACTIONS FOR FLUCONAZOLE CIMETIDINE: DECREASED EFFICACY OF FLUCONAZOLE. CYCLOSPORINE: INCREASE IN SERUM CYCLOSPORINE PLASMA CONCENTRATION. HYDROCHLOROTHIAZIDE: REDUCTION IN RENAL CLEARANCE OF FLUCONAZOLE. PHENYTOIN: EFFICACY OF PHENYTOIN ENHANCED. RIFAMPICIN: EFFICACY OF FLUCONAZOLE DECREASED HIGHER DOSAGE REQUIRED. SULFONYLUREAS: EFFICACY OF TOLBUTAMIDE GLYBURIDE AND GLIPIZIDE INCREASED. WARFARIN: POTENTIATES THE ANTICOAGULANT EFFECT RESULTING IN INCREASE IN PROTHROMBIN TIME. INDICATIONS FOR FLUCONAZOLE 1.OESOPHAGEAL CANDIDIASIS 2.OROPHARYNGEAL CANDIDIASIS 3.VAGINAL CANDIDIASIS 4.SYSTEMIC CANDIDIASIS 5.CRYPTOC