AMBISOME 50MG I.V. VIAL

ABOUT AMPHOTERICIN-B IT IS A POLYENE ANTIFUNGAL ANTIBIOTIC. INDICATIONS FOR AMPHOTERICIN-B 1.ORAL CUTANEOUS VAGINAL CANDIDIASIS 2.OTOMYCOSIS 3.MUCOCUTANEOUS CANDIDIASIS 4.FUNGAL MENINGITIS 5.KALA AZAR 6.CRYPTOCOCCOSIS 7.HISTOPLASMOSIS 8.COCCIDIOIDOMYCOSIS 9.BLASTOMYCOSIS 10.PARACOCCIDIOIDOMYCOSIS 11.ASPERGILLOSIS 12.SPOROTRICHOSIS 13.SYSTEMIC MYCOSES MECHANISM OF ACTION OF AMPHOTERICIN-B AMPHOTERICIN B HAS HIGH AFFINITY FOR ERGOSTEROL PRESENT IN THE FUNGAL CELL MEMBRANE AND BIND WITH IT AND THEY ORIENTS IN SUCH A WAY THAT MICROPORE CHANNEL ARE FORMED AND LEADS TO EFFLUX OF IONS AMINO ACID SUGAR AND OTHER WATER SOLUBLE SUBSTANCES AND RESULTS IN CELL DISRUPTION.